WebIntroduction: Necrotizing autoimmune myopathy (NAM) is strongly associated with pathognomonic autoantibodies targeting 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) or signal recognition particle (SRP), whose levels in turn are correlated with serum creatine kinase (CK) and necrosis. WebApr 9, 2024 · Pinal-Fernandez I, Casal-Dominguez M, Derfoul A, Pak K, Plotz P, Miller FW, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Paik J, Albayda J, Christopher-Stine L, Lloyd TE, Corse AM, Mammen AL. Identification of distinctive interferon gene signatures in different types of myositis. Neurology. 2024 Sep 17;93(12):e1193-e1204. doi: …
Treatment of Refractory Anti-HMG-CoA Reductase …
WebMyositis. The literal translation of myositis is "muscle inflammation." This inflammation is caused by white blood cells called lymphocytes, which are normally supposed to protect … WebOct 22, 2024 · Anti-HMGCR and anti-SRP myositis-specific autoantibodies seem to play a key role in the pathophysiology of IMNM; autoantibody-induced muscle damage is … fresh seafood market in 23233
Andrew Mammen, M.D., Ph.D. - Johns Hopkins …
WebImmune-mediated necrotizing myopathy (IMNM) is a distinct subgroup of inflammatory myopathy typically characterized by myofiber necrosis with minimal inflammatory … WebMar 8, 2024 · The researchers enrolled 104 patients with anti-HMGCR associated myositis who were seen for their clinical care at the Johns Hopkins Myositis Centre and studied … WebAnti-hydroxymethylglutaryl CoA reductase (HMGCR) myopathy is a subtype of myositis characterized by proximal muscle weakness, elevated serum creatine kinase (CK) levels, and autoantibodies recognizing HMGCR1. While statins are an established risk factor for developing anti-HMGCR myopathy in older patients, some individuals fresh seafood market holden beach nc