Dynein intermediate chain

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August undefined, 2024

WebThe dynein light intermediate chain (LIC) is a subunit unique to the cytoplasmic form of dynein, but how it contributes to dynein function is not fully understood. Previous work has established that the LIC homodimer binds directly to the dynein heavy chain and may mediate the attachment of dynein to centrosomes and other cargoes. Here, we ... WebJan 13, 1997 · Among the inner dynein arms is a structure referred to as inner arm I1 that is located in the proximal portion of each 96-nm repeat, composed of two heavy chains and three intermediate chain subunits with masses of 140, 138, and 97 kD, and can be isolated as a 21S particle or in the “f” fraction separated by Mono-Q chromatography ...

Dynein light intermediate chains as pivotal determinants …

WebFeb 6, 2024 · Previous studies have revealed that all tested cargo adaptors bind two subunits of dynein: the light-intermediate chain and the heavy chain [8. Lee I.-G. et al. A conserved interaction of the dynein light intermediate chain with dynein–dynactin effectors necessary for processivity. Nat. Commun. 2024; 9: 986. Crossref; WebAug 26, 2024 · (c, d) Comparison of the β-propeller domains of dynein-2’s heterodimeric intermediate chains, WDR60 and WDR34 (c) with dynein-1’s homodimeric intermediate chain (IC2) (d), following alignment ... optimum new bern nc office

The dynein family at a glance - The Company of Biologists

WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated … WebDec 8, 2024 · Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2 cl29593 Location: 266 → 589 WD40; WD40 domain, found in a number of eukaryotic proteins that cover a … WebOct 15, 2007 · This dynein is a HC homodimer and contains two intermediate chains (ICs), two light intermediate chains (LICs) as well as at least three different light chain (LC) dimers of the LC8 (DYNLL), Roadblock/LC7 (DYNLRB) and Tctex1 (DYNLT) families (Pfister et al., 2006). By contrast, to date only three proteins – an isoform-specific HC … optimum networks

Anti-Dynein Antibody, 74 kDa Intermediate chains, cytoplasmic, …

The dynein heavy chain: structure, mechanics and evolution

WebMar 21, 2024 · This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The … WebThe light intermediate chains associate in the dynein complex only as homoligomers. b Each light chain family has at least 2 members. Table II. Composition of … optimum newsWebMay 1, 2001 · The intermediate- and light-chains help specify the intracellular location of the dynein and regulate its motor activity. ... Many organisms express multiple dynein heavy chain genes that encode distinct protein isoforms. The dynein heavy chain family of isoforms is divided into four functional classes: (i) axonemal (ciliary or flagellar) outer ... optimum notary signing services

"WebNov 1, 2006 · Isoforms of the intermediate chain (IC) family bind to some axonemal dyneins and cytoplasmic dynein 1 but not cytoplasmic dynein 2. ... The third P-loop domain in cytoplasmic dynein heavy chain is essential for dynein motor function and ATP-sensitive microtubule binding. Mol. Biol. Cell. 14, 1355-1365. Summers, K. E. and Gibbons, I. R. … " - Dynein intermediate chain

Dynein intermediate chain

WebOct 15, 2024 · Our results indicate that the subunit asymmetry within the dynein-2 complex is matched with a functional asymmetry between the dynein-2 intermediate chains. Furthermore, this work reveals that loss … WebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation …

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WebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing. WebCytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein …

Web1 day ago · Outer dynein arms in the ciliary axoneme generate force for ciliary beating. Here, cryo-electron tomography study of the outer dynein arm from the unicellular alga … WebCytoplasmic dynein is a member of the dynein superfamily of proteins. It is a massive multisubunit complex (1.2 MD) composed of two heavy chains (∼530 kD), three intermediate chains (74 kD), and four light intermediate chains (∼55 kD), and moves along microtubules toward their minus ends (13, 23) (Fig.5).

WebDec 8, 2024 · Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2 cl29593 Location: 266 → 589 WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 …

WebAll lanes : Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11222] (ab156567) at 1/1000 dilution Lane 1 : Fetal brain lysate Lane 2 : Human hypothalamus lysate Lysates/proteins at 10 µg per lane. Secondary All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution Predicted band size: 79 kDa

WebCoordinated movement of the dynein arms causes the entire axoneme to bend back and forth. IDAs and ODAs have different combinations of protein components (subunits) that … portland pottery for saleWeb604366 - DYNEIN, AXONEMAL, INTERMEDIATE CHAIN 1; DNAI1 - DNAI1 In a 9-year-old boy with immotile cilia syndrome unassociated with situs inversus, Pennarun et al. (1999) found compound heterozygosity for 2 mutations in the DNAI1 gene: a 1-bp insertion (T) at nucleotide +3 of the intronic splice donor sequence following exon 1, which was inherited … optimum newsdayWebGene ID: 118457500, updated on 21-Dec-2024. Summary Other designations. cytoplasmic dynein 1 intermediate chain-like optimum news channelsWebJul 21, 2010 · Background Intracellular transport of cargoes including organelles, vesicles, signalling molecules, protein complexes, and RNAs, is essential for normal function of … optimum no rinse washWebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … optimum new residential customers onlyWebSupply chain/systems analysis experience is a plus Problem-Solving Intermediate level proficiency in MS Excel (experience needed with cutting & pasting around text, … optimum newsmaxWebThe deduced protein contains a P-loop near the N terminus. Using primers based on mouse and chicken dynein Lic1, Bielli et al. (2001) amplified human DYNC1LI1, which they … portland pottery supply store